Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans

Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans

Rtf1 is generally considered to be a subunit of the Paf1 complex (Paf1C), which is a multifunctional protein complex involved in histone modification and RNA biosynthesis at multiple stages. Rtf1 is stably associated with the Paf1C in Saccharomyces cerevisiae, but not in other species including huma...

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Bibliographic Details
Main Authors: Yixuan Jiang, Ying Liang, Fujie Zhao, Zhenguo Lu, Siyu Wang, Yao Meng, Zhanxiang Liu, Jing Zhang, Youbao Zhao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
Rtf1
histone modification domain
H2B ubiquitination
Cryptococcus neoformans
yeast-to-hypha transition
virulence
Online Access:https://elifesciences.org/articles/99229
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https://elifesciences.org/articles/99229

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