HDL cholesterol as a mediator of the relationship between breastfeeding and coronary atherosclerosis from a two-step Mendelian randomization analysis

HDL cholesterol as a mediator of the relationship between breastfeeding and coronary atherosclerosis from a two-step Mendelian randomization analysis

Abstract The association between breastfeeding and coronary atherosclerosis (CA) is still controversial. In this study, we employed Mendelian randomization (MR) analysis to inverstigate the association between breastfeeding and CA, and to identify potential mediators underlying this link. Breastfeed...

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Bibliographic Details
Main Authors: Baoquan Zhang, Bin Yang, Wenlong Xiu, Dongyu Xue, Yiping Zheng, Jin Wei, Yue Dai
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Breastfeeding
Coronary atherosclerosis
High-density lipoprotein cholesterol
Mendelian randomization
Online Access:https://doi.org/10.1038/s41598-025-12369-w
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https://doi.org/10.1038/s41598-025-12369-w

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