Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages

Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages

Abstract Background Inflammatory bowel disease (IBD), a chronic immune disorder, has increasing global incidence and poor treatment outcome. Abnormal macrophage function is implicated in the pathophysiology of IBD. In this study, we investigated the mechanism by which human umbilical cord mesenchyma...

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Bibliographic Details
Main Authors: Mengjiao Zhou, Bing Pei, Peipei Cai, Chengxue Yi, Francis Atim Akanyibah, Changkun Lyu, Fei Mao
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Stem Cell Research & Therapy
Subjects:
hucMSC-Ex
Macrophage
SIRT1-FXR pathway
NLRP3 inflammasome
IBD
Online Access:https://doi.org/10.1186/s13287-025-04365-8
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https://doi.org/10.1186/s13287-025-04365-8

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