Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota
Background Research has showcased a correlation between disruptions in gut microbiota and primary membranous nephropathy (pMN), giving rise to the concept of the ‘gut-kidney axis’. However, the precise relationship between gut microbiota and pMN remains elusive. Hence, this study endeavors to invest...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2349136 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591127735173120 |
|---|---|
| author | Jianwei Wu Jing Zhang Gang Huang Yinglian Zhong Yi Yang Peng Deng |
| author_facet | Jianwei Wu Jing Zhang Gang Huang Yinglian Zhong Yi Yang Peng Deng |
| author_sort | Jianwei Wu |
| collection | DOAJ |
| description | Background Research has showcased a correlation between disruptions in gut microbiota and primary membranous nephropathy (pMN), giving rise to the concept of the ‘gut-kidney axis’. However, the precise relationship between gut microbiota and pMN remains elusive. Hence, this study endeavors to investigate whether a causal relationship exists between gut microbiota and pMN utilizing Mendelian randomization (MR) analysis.Methods The primary method employed for MR analysis is the inverse variance weighting method, supplemented by MR-Egger and the weighted median method, to infer causality. This approach was validated within the pMN cohort across two distinct populations.Results At the species level, the abundance of Bifidobacterium bifidum and Alistipes indistinctus was negatively correlated with the risk of pMN. Conversely, pMN was positively associated with Bacilli abundance at the class level, Lachnospiraceae abundance at the family level, and Dialister abundance at the genus level. Specifically, at the species level, pMN was positively correlated with the abundance of Ruminococcus lactaris, Dialister invisus, and Coprococcus_sp_ART55_1.Conclusion These findings lay the groundwork for future research exploring the interplay between pMN and the gut microbiota, with substantial implications for the prevention and treatment of pMN and its associated complications. |
| format | Article |
| id | doaj-art-cb3fa0004e664512aebab54598515111 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-cb3fa0004e664512aebab545985151112025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2349136Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiotaJianwei Wu0Jing Zhang1Gang Huang2Yinglian Zhong3Yi Yang4Peng Deng5Department of Medical Technology, Gannan Healthcare Vocational College, Ganzhou, ChinaDepartment of Medical Technology, Gannan Healthcare Vocational College, Ganzhou, ChinaDepartment of Laboratory, GanZhou Cancer Hospital, Ganzhou, ChinaDepartment of Blood Transfusion, Ganzhou Fifth People’s Hospital, Ganzhou, ChinaDepartment of Rheumatology and Immunology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Endocrinology, Department of Nephrology, Ganzhou Fifth People’s Hospital, Ganzhou, ChinaBackground Research has showcased a correlation between disruptions in gut microbiota and primary membranous nephropathy (pMN), giving rise to the concept of the ‘gut-kidney axis’. However, the precise relationship between gut microbiota and pMN remains elusive. Hence, this study endeavors to investigate whether a causal relationship exists between gut microbiota and pMN utilizing Mendelian randomization (MR) analysis.Methods The primary method employed for MR analysis is the inverse variance weighting method, supplemented by MR-Egger and the weighted median method, to infer causality. This approach was validated within the pMN cohort across two distinct populations.Results At the species level, the abundance of Bifidobacterium bifidum and Alistipes indistinctus was negatively correlated with the risk of pMN. Conversely, pMN was positively associated with Bacilli abundance at the class level, Lachnospiraceae abundance at the family level, and Dialister abundance at the genus level. Specifically, at the species level, pMN was positively correlated with the abundance of Ruminococcus lactaris, Dialister invisus, and Coprococcus_sp_ART55_1.Conclusion These findings lay the groundwork for future research exploring the interplay between pMN and the gut microbiota, with substantial implications for the prevention and treatment of pMN and its associated complications.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2349136Gut microbiotaprimary membranous nephropathymendelian randomizationgenome-wide association |
| spellingShingle | Jianwei Wu Jing Zhang Gang Huang Yinglian Zhong Yi Yang Peng Deng Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota Renal Failure Gut microbiota primary membranous nephropathy mendelian randomization genome-wide association |
| title | Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota |
| title_full | Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota |
| title_fullStr | Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota |
| title_full_unstemmed | Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota |
| title_short | Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota |
| title_sort | evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota |
| topic | Gut microbiota primary membranous nephropathy mendelian randomization genome-wide association |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2349136 |
| work_keys_str_mv | AT jianweiwu evidencefrommendelianrandomizationidentifiesseveralcausalrelationshipsbetweenprimarymembranousnephropathyandgutmicrobiota AT jingzhang evidencefrommendelianrandomizationidentifiesseveralcausalrelationshipsbetweenprimarymembranousnephropathyandgutmicrobiota AT ganghuang evidencefrommendelianrandomizationidentifiesseveralcausalrelationshipsbetweenprimarymembranousnephropathyandgutmicrobiota AT yinglianzhong evidencefrommendelianrandomizationidentifiesseveralcausalrelationshipsbetweenprimarymembranousnephropathyandgutmicrobiota AT yiyang evidencefrommendelianrandomizationidentifiesseveralcausalrelationshipsbetweenprimarymembranousnephropathyandgutmicrobiota AT pengdeng evidencefrommendelianrandomizationidentifiesseveralcausalrelationshipsbetweenprimarymembranousnephropathyandgutmicrobiota |