Blocking of Tim‐3 Ameliorates Spinal Cord Ischemia‐Reperfusion Injury Through Inhibiting Neuroinflammation and Promoting M1‐to‐M2 Phenotypic Polarization of Microglia
ABSTRACT Background Blocking of Tim‐3 exerts therapeutic effects in a series of ischemia‐reperfusion injury (IRI). Methods In this work, a cross‐clamped aortic arch was conducted to establish SCIRI rat model. Besides, rat spinal microglia was subjected to OGD/R to mimic I/R‐like conditions in vitro....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-12-01
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| Series: | Immunity, Inflammation and Disease |
| Online Access: | https://doi.org/10.1002/iid3.70084 |
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