A multimodal approach for establishing ACTL6A and ERCC1 as chemoresistance genes in locally advanced head and neck cancer

A multimodal approach for establishing ACTL6A and ERCC1 as chemoresistance genes in locally advanced head and neck cancer

BackgroundDNA is generally considered the ultimate target of cisplatin, so DNA repair has become the hallmark for cisplatin chemoresistance that is attributed to the poor overall survival (50%) among patients with head and neck cancer (HNC). As the efficacy of cisplatin is dose-dependent, we conduct...

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Bibliographic Details
Main Authors: Raushan Kumar Chaudhary, Prakash Patil, Vijith Vittal Shetty, Uday Venkat Mateti, Praveenkumar Shetty
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
chemoradiotherapy
chemoresistance
cisplatin
DNA repair
drug repurposing
evidence
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1541987/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1541987/full

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