Biomimetic mesenchymal stem cell membrane-coated nanoparticle delivery of MKP5 inhibits hepatic fibrosis through the IRE/XBP1 pathway

Biomimetic mesenchymal stem cell membrane-coated nanoparticle delivery of MKP5 inhibits hepatic fibrosis through the IRE/XBP1 pathway

Abstract Hepatic fibrosis is a common disease with high morbidity and mortality rates. The complex and poorly understood mechanisms underlying hepatic fibrosis represent a significant challenge for the development of more effective therapeutic strategies. MKP5 is a potential regulator of multiple fi...

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Bibliographic Details
Main Authors: Yafei Tian, Dandan Sun, Na Liu, Jianan Zhao, Tongjian Zhao, Xiaonan Liu, Xinzhe Dong, Li Dong, Wei Wang, Ping Jiao, Jie Ma
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Nanobiotechnology
Subjects:
Hepatic fibrosis
MKP5
HSCs activation
Hepatocytes apoptosis
Nano-delivery system, Mesenchymal stem cell membrane
Online Access:https://doi.org/10.1186/s12951-024-03029-8
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https://doi.org/10.1186/s12951-024-03029-8

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