Exceptional response to the ATR inhibitor, camonsertib, in a patient with ALT+ metastatic melanoma

Exceptional response to the ATR inhibitor, camonsertib, in a patient with ALT+ metastatic melanoma

Abstract A key hallmark of cancer tumorigenesis is the maintenance of telomere length, which occurs canonically through the reactivation of telomerase. Alternative lengthening of telomeres (ALT) is an atypical, non-canonical telomere maintenance mechanism that uses homologous recombination (HR) to m...

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Main Authors: Natalie Y. L. Ngoi, Ian M. Silverman, Adrienne Johnson, Chenfeng Meng, Joseph D. Schonhoft, Michal Zimmermann, Danielle Ulanet, Hyeyeon Kim, Carlos Torrado, Carolina Salguero, Christian Valladolid Brown, Jordi Rodon, Victoria Rimkunas, Maria Koehler, Timothy A. Yap
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01025-1
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https://doi.org/10.1038/s41698-025-01025-1

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