Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study
Objectives To investigate whether the metabolically important visceral adipose tissue (VAT) relates differently to structural and functional brain changes in comparison with body weight measured as body mass index (BMI). Moreover, we aimed to investigate whether these effects change with age.Design...
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BMJ Publishing Group
2013-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/3/1/e001915.full |
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| author | Yvonne Böttcher Michael Stumvoll Kees Straatman Matthias Raschpichler Matthias Leopold Schroeter Katrin Arelin Haiko Schlögl Dominik Fritzsch Meinhard Mende André Pampel Arno Villringer Karsten Mueller |
| author_facet | Yvonne Böttcher Michael Stumvoll Kees Straatman Matthias Raschpichler Matthias Leopold Schroeter Katrin Arelin Haiko Schlögl Dominik Fritzsch Meinhard Mende André Pampel Arno Villringer Karsten Mueller |
| author_sort | Yvonne Böttcher |
| collection | DOAJ |
| description | Objectives To investigate whether the metabolically important visceral adipose tissue (VAT) relates differently to structural and functional brain changes in comparison with body weight measured as body mass index (BMI). Moreover, we aimed to investigate whether these effects change with age.Design Cross-sectional, exploratory.Setting University Clinic, Integrative Research and Treatment Centre.Participants We included 100 (mean BMI=26.0 kg/m², 42 women) out of 202 volunteers randomly invited by the city's registration office, subdivided into two age groups: young-to-mid-age (n=51, 20–45 years of age, mean BMI=24.9, 24 women) versus old (n=49, 65–70 years of age, mean BMI=27.0, 18 women).Main outcome measures VAT, BMI, subcutaneous abdominal adipose tissue, brain structure (grey matter density), functional brain architecture (eigenvector centrality, EC).Results We discovered a loss of cerebellar structure with increasing VAT in the younger participants, most significantly in regions involved in motor processing. This negative correlation disappeared in the elderly. Investigating functional brain architecture showed again inverse VAT–cerebellum correlations, whereas now regions involved in cognitive and emotional processing were significant. Although we detected similar results for EC using BMI, significant age interaction for both brain structure and functional architecture was only found using VAT.Conclusions Visceral adiposity is associated with cerebellar changes of both structure and function, whereas the regions involved contribute to motor, cognitive and emotional processes. Furthermore, these associations seem to be age dependent, with younger adults’ brains being adversely affected. |
| format | Article |
| id | doaj-art-cae0bb2f33b44313ad9f02578aa67237 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-cae0bb2f33b44313ad9f02578aa672372025-02-07T12:00:10ZengBMJ Publishing GroupBMJ Open2044-60552013-01-013110.1136/bmjopen-2012-001915Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory studyYvonne Böttcher0Michael Stumvoll1Kees Straatman2Matthias Raschpichler3Matthias Leopold Schroeter4Katrin Arelin5Haiko Schlögl6Dominik Fritzsch7Meinhard Mende8André Pampel9Arno Villringer10Karsten Mueller111Leipzig University Medical Center, IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany8 Medical Department III Endocrinology Nephrology Rheumatology, University of Leipzig Medical Center, Leipzig, Germany2Advanced Imaging Facilities, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK1Leipzig University Medical Center, IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany3Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany5Clinic for Cognitive Neurology, University of Leipzig, Leipzig, Germany7 Medical Department III Endocrinology Nephrology Rheumatology, University of Leipzig Medical Center, Leipzig, Germany7Department for Neuroradiology, University of Leipzig, Leipzig, Germany8Clinical Trial Centre Leipzig, University of Leipzig, Leipzig, Germany3Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany1 Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany3Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyObjectives To investigate whether the metabolically important visceral adipose tissue (VAT) relates differently to structural and functional brain changes in comparison with body weight measured as body mass index (BMI). Moreover, we aimed to investigate whether these effects change with age.Design Cross-sectional, exploratory.Setting University Clinic, Integrative Research and Treatment Centre.Participants We included 100 (mean BMI=26.0 kg/m², 42 women) out of 202 volunteers randomly invited by the city's registration office, subdivided into two age groups: young-to-mid-age (n=51, 20–45 years of age, mean BMI=24.9, 24 women) versus old (n=49, 65–70 years of age, mean BMI=27.0, 18 women).Main outcome measures VAT, BMI, subcutaneous abdominal adipose tissue, brain structure (grey matter density), functional brain architecture (eigenvector centrality, EC).Results We discovered a loss of cerebellar structure with increasing VAT in the younger participants, most significantly in regions involved in motor processing. This negative correlation disappeared in the elderly. Investigating functional brain architecture showed again inverse VAT–cerebellum correlations, whereas now regions involved in cognitive and emotional processing were significant. Although we detected similar results for EC using BMI, significant age interaction for both brain structure and functional architecture was only found using VAT.Conclusions Visceral adiposity is associated with cerebellar changes of both structure and function, whereas the regions involved contribute to motor, cognitive and emotional processes. Furthermore, these associations seem to be age dependent, with younger adults’ brains being adversely affected.https://bmjopen.bmj.com/content/3/1/e001915.full |
| spellingShingle | Yvonne Böttcher Michael Stumvoll Kees Straatman Matthias Raschpichler Matthias Leopold Schroeter Katrin Arelin Haiko Schlögl Dominik Fritzsch Meinhard Mende André Pampel Arno Villringer Karsten Mueller Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study BMJ Open |
| title | Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study |
| title_full | Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study |
| title_fullStr | Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study |
| title_full_unstemmed | Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study |
| title_short | Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study |
| title_sort | abdominal fat distribution and its relationship to brain changes the differential effects of age on cerebellar structure and function a cross sectional exploratory study |
| url | https://bmjopen.bmj.com/content/3/1/e001915.full |
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