Mechanistic role of FN1 in LAIR-1 mediated downregulation of ovarian cancer cell proliferation

Mechanistic role of FN1 in LAIR-1 mediated downregulation of ovarian cancer cell proliferation

Abstract Objective RNA-seq was used to explore the potential mechanism underlying human leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) inhibition of the proliferation and migration of ovarian cancer cells. Method A LAIR-1–overexpression cell model was established using a LAIR-1-lentivi...

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Bibliographic Details
Main Authors: Huachang Zhang, Mengke Liu, Hao Zhong, Li Ma, Yunyi Liu, Chuntong Liu, Shude Yang, Bin Wang, Jing An, Shuling Song, Qizhi Cao
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cancer
Subjects:
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1)
Fibronectin 1 (FN1)
Ovarian cancer (OC)
MAPK
Proliferation
RNA-seq
Online Access:https://doi.org/10.1186/s12885-025-13692-1
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https://doi.org/10.1186/s12885-025-13692-1

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