Alternatively spliced isoforms of IRF7 differentially regulate interferon expression to tune response to viral infection

Alternatively spliced isoforms of IRF7 differentially regulate interferon expression to tune response to viral infection

Summary: Interferon regulatory factor 7 (IRF7) is a master transcriptional regulator of innate immunity. IRF7 binds as a homodimer, or heterodimer with IRF3, to promoters of type I interferons (IFN-Is) to drive their expression, which activates expression of antiviral genes. Here, we demonstrate tha...

Full description

Saved in:
Bibliographic Details
Main Authors: Asmita Panthi, Max B. Ferretti, Olivia Howard, Swechha Mainali Pokharel, Rhiannon McCracken, Simon Boudreault, Mathieu Quesnel-Vallieres, Qin Li, Sara Cherry, Kristen W. Lynch
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725009374
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2211124725009374

Similar Items