HIV-1 protease and reverse transcriptase control the architecture of their nucleocapsid partner.

HIV-1 protease and reverse transcriptase control the architecture of their nucleocapsid partner.

The HIV-1 nucleocapsid is formed during protease (PR)-directed viral maturation, and is transformed into pre-integration complexes following reverse transcription in the cytoplasm of the infected cell. Here, we report a detailed transmission electron microscopy analysis of the impact of HIV-1 PR and...

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Main Authors: Gilles Mirambeau, Sébastien Lyonnais, Dominique Coulaud, Laurence Hameau, Sophie Lafosse, Josette Jeusset, Isabelle Borde, Michèle Reboud-Ravaux, Tobias Restle, Robert J Gorelick, Eric Le Cam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-08-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000669&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000669&type=printable

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