CDCP1 knockdown suppresses PDGFRβ/AKT pathway-mediated vascular smooth muscle cell proliferation by inhibiting PDGFRβ endocytosis

CDCP1 knockdown suppresses PDGFRβ/AKT pathway-mediated vascular smooth muscle cell proliferation by inhibiting PDGFRβ endocytosis

CUB domain-containing protein 1 (CDCP1) is a type of cell surface glycoprotein that has been identified as being capable of regulating cell anchorage, migration, proliferation, and differentiation. However, the contributions of CDCP1 in intimal hyperplasia, specifically regarding the proliferation a...

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Bibliographic Details
Main Authors: Xin Ji, Xin Wang, Qianqian Dong, Wanqiu Li, Ning Zhou, Xiaole Yue, Dandan Zhao, Xiaolong Yang
Format: Article
Language:English
Published: PeerJ Inc. 2025-04-01
Series:PeerJ
Subjects:
Intimal hyperplasia
CDCP1
PDGFRβ
AKT signaling
Clathrin
Endocytosis
Online Access:https://peerj.com/articles/19114.pdf
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