Expression of DNAJB1-PRKACA oncogene suppresses the differentiation potential of liver progenitor organoids towards a hepatocyte lineage

Expression of DNAJB1-PRKACA oncogene suppresses the differentiation potential of liver progenitor organoids towards a hepatocyte lineage

Abstract Fibrolamellar carcinoma (FLC) is a type of primary liver cancer that predominantly affects healthy adolescents and young adults in a background of normal liver. The DNAJB1-PRKACA fusion gene is an oncogenic driver in FLC tumors. To investigate the oncogenic mechanisms of this fusion gene, w...

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Main Authors: Emma DiPietro, Nihal Bharath, Michael Karski, Olivia Durfee, Marc S. Sherman, Qianyi Ma, Liang Sun, Alaa R. Farghli, Colton J. Smith, Ina Kycia, Praveen Sethupathy, Wolfram Goessling, Michael S. Rogers, Khashayar Vakili
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-11028-4
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https://doi.org/10.1038/s41598-025-11028-4

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