Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices
Background and Aim. Myeloid-derived suppressor cells (MDSCs) contribute to the process of malignant transformation and tumor progression through immuno- and nonimmunosuppressive mechanisms. The current study is aimed at providing the predictive and prognostic role of Mo-MDSCs in advanced non-small-c...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/3241150 |
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| author | Asmaa M. Zahran Helal F. Hetta Zeinab Albadry M. Zahran Alaa Rashad Amal Rayan Dalia O. Mohamed Zeinab Ahmed Abd Elhameed Salah M. Khallaf Gaber El-Saber Batiha Yasir Waheed Khalid Muhammad Hanaa Nafady-Hego |
| author_facet | Asmaa M. Zahran Helal F. Hetta Zeinab Albadry M. Zahran Alaa Rashad Amal Rayan Dalia O. Mohamed Zeinab Ahmed Abd Elhameed Salah M. Khallaf Gaber El-Saber Batiha Yasir Waheed Khalid Muhammad Hanaa Nafady-Hego |
| author_sort | Asmaa M. Zahran |
| collection | DOAJ |
| description | Background and Aim. Myeloid-derived suppressor cells (MDSCs) contribute to the process of malignant transformation and tumor progression through immuno- and nonimmunosuppressive mechanisms. The current study is aimed at providing the predictive and prognostic role of Mo-MDSCs in advanced non-small-cell lung cancer (NSCLC) in relation to different hematologic indices. Methods. We recruited 40 cases of advanced NSCLC, stages III and IV, aged>18–<70 years old, and eligible to receive chemotherapy with or without radiotherapy, along with 20 healthy controls of comparable age and sex; after diagnosis and staging of patients, blood samples were collected for flow cytometric detection of Mo-MDSCs. Results. Significant accumulation of Mo-MDSCs in patients compared to their controls (p<0.0001). Furthermore, these cells accumulated significantly in stage IV compared to stage III (p=0.006) and correlated negatively with overall survival (r=−0.471, p=0.002), lymphocyte to monocyte ratio (r=−0.446, p=0.004), and mean platelet volume to platelet count ratio (MPV/PC) (r=−0.464, p=0.003), patients with Mo‐MDSCs<13% had significantly better survival than those with Mo‐MDSCs≥13% (p=0.041). Conclusion. Mo-MDSCs represent one of the key mechanisms in the immunosuppressive tumor microenvironment (TME) to play major roles not only in the carcinogenesis of lung cancer but also in disease progression and prognosis and, in addition, predict the efficacy of immune checkpoint inhibitors; our results provided some support to target Mo-MDSCs and needed to be augmented by further studies. |
| format | Article |
| id | doaj-art-ca97d5c390fe4e4ba3d34891a81ae4b6 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-ca97d5c390fe4e4ba3d34891a81ae4b62025-02-03T01:25:48ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/32411503241150Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic IndicesAsmaa M. Zahran0Helal F. Hetta1Zeinab Albadry M. Zahran2Alaa Rashad3Amal Rayan4Dalia O. Mohamed5Zeinab Ahmed Abd Elhameed6Salah M. Khallaf7Gaber El-Saber Batiha8Yasir Waheed9Khalid Muhammad10Hanaa Nafady-Hego11Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, EgyptDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71526, EgyptDepartment of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, EgyptDepartment of Chest Diseases and Tuberculosis, Qena Faculty of Medicine, South Valley University, EgyptClinical Oncology Department, Faculty of Medicine, Assiut University, EgyptRadiation Oncology Department, South Egypt Cancer Institute, Assiut University, EgyptDepartment of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, EgyptMedical Oncology Department, South Egypt Cancer Institute, Assiut University, EgyptDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Damanhour City, EgyptFoundation University Medical College, Foundation University Islamabad, Islamabad 44000, PakistanDepartment of Biology, College of Science, United Arab Emirates University, Al Ain 15551, UAEDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71526, EgyptBackground and Aim. Myeloid-derived suppressor cells (MDSCs) contribute to the process of malignant transformation and tumor progression through immuno- and nonimmunosuppressive mechanisms. The current study is aimed at providing the predictive and prognostic role of Mo-MDSCs in advanced non-small-cell lung cancer (NSCLC) in relation to different hematologic indices. Methods. We recruited 40 cases of advanced NSCLC, stages III and IV, aged>18–<70 years old, and eligible to receive chemotherapy with or without radiotherapy, along with 20 healthy controls of comparable age and sex; after diagnosis and staging of patients, blood samples were collected for flow cytometric detection of Mo-MDSCs. Results. Significant accumulation of Mo-MDSCs in patients compared to their controls (p<0.0001). Furthermore, these cells accumulated significantly in stage IV compared to stage III (p=0.006) and correlated negatively with overall survival (r=−0.471, p=0.002), lymphocyte to monocyte ratio (r=−0.446, p=0.004), and mean platelet volume to platelet count ratio (MPV/PC) (r=−0.464, p=0.003), patients with Mo‐MDSCs<13% had significantly better survival than those with Mo‐MDSCs≥13% (p=0.041). Conclusion. Mo-MDSCs represent one of the key mechanisms in the immunosuppressive tumor microenvironment (TME) to play major roles not only in the carcinogenesis of lung cancer but also in disease progression and prognosis and, in addition, predict the efficacy of immune checkpoint inhibitors; our results provided some support to target Mo-MDSCs and needed to be augmented by further studies.http://dx.doi.org/10.1155/2021/3241150 |
| spellingShingle | Asmaa M. Zahran Helal F. Hetta Zeinab Albadry M. Zahran Alaa Rashad Amal Rayan Dalia O. Mohamed Zeinab Ahmed Abd Elhameed Salah M. Khallaf Gaber El-Saber Batiha Yasir Waheed Khalid Muhammad Hanaa Nafady-Hego Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices Journal of Immunology Research |
| title | Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices |
| title_full | Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices |
| title_fullStr | Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices |
| title_full_unstemmed | Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices |
| title_short | Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices |
| title_sort | prognostic role of monocytic myeloid derived suppressor cells in advanced non small cell lung cancer relation to different hematologic indices |
| url | http://dx.doi.org/10.1155/2021/3241150 |
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