Synergistic effect of 5-fluorouracil and the small molecule Wnt/β-catenin inhibitor iCRT3 on Caco-2 colorectal cancer cells in vitro
Although 5-fluorouracil (5-FU) is a cornerstone of colorectal cancer (CRC) treatment, its efficacy is often limited by resistance. Wnt/β-catenin signalling plays a crucial role in CRC carcinogenesis and resistance, as Wnt expression is upregulated in 5-FU-resistant cells, protecting them from cell c...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025010874 |
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