<i>In vivo</i> evaluation of tropism and biodistribution of synthetic and natural adeno-associated viral vectors by next-generation sequencing

<i>In vivo</i> evaluation of tropism and biodistribution of synthetic and natural adeno-associated viral vectors by next-generation sequencing

INTRODUCTION. The creation of synthetic adeno-associated virus (AAV) vectors during gene therapy development is a labour-intensive and expensive process. The optimal solution to minimise the time and costs associated with gene therapy development lies in the improvement of methods aimed at assessing...

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Main Authors: D. O. Maksimov, D. A. Naumova, E. A. Astakhova, V. V. Artemev, S. A. Biryukov, I. S. Abramov, A. A. Navoikova, N. V. Rudev, S. G. Feoktistova, O. V. Glazova, O. N. Mityaeva, P. Yu. Volchkov
Format: Article
Language:Russian
Published: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2024-07-01
Series:Биопрепараты: Профилактика, диагностика, лечение
Subjects:
adeno-associated virus
aav
synthetic vector
synthetic vector library
aav library
barcoding
dna barcode
rna barcode
aav serotypes
next-generation sequencing
ngs
bioinformatics analysis
biodistribution
transduction efficiency in vivo
tropism
gene therapy
Online Access:https://www.biopreparations.ru/jour/article/view/582
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