Deletion of the transcription factor ATF4 in a model of clear cell renal cell carcinoma

Deletion of the transcription factor ATF4 in a model of clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer in adults. We generated TRAnsgenic of Cancer of the Kidney (TRACK) mice that express a triple-mutant (P402A, P564A, and N803A) human HIF1α construct specifically in their proximal tubule (PT) cells. We demonstrated that...

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Bibliographic Details
Main Authors: Yuling Chi, Shireen Chikara, Eduardo Mere Del Aguila, Tuo Zhang, Jacob B. Geri, David M. Nanus, Lorraine J. Gudas
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Clear cell renal cell carcinoma
Activating transcription factor 4
Transcriptomics
Proteomics
Fatty acids
ATP citrate lyase
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000673
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