Mechanisms of sorafenib-induced cardiotoxicity: ER stress induces upregulation of ATF3, leading to downregulation of NDUFS1 expression and mitochondrial dysfunction

Mechanisms of sorafenib-induced cardiotoxicity: ER stress induces upregulation of ATF3, leading to downregulation of NDUFS1 expression and mitochondrial dysfunction

BackgroundSorafenib, a widely used tyrosine kinase inhibitor (TKI), has been associated with cardiotoxic effects; however, the precise molecular basis of this toxicity remains incompletely characterized. This study examined sorafenib’s impact on cardiac cells, focusing on endoplasmic reticulum (ER)...

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Bibliographic Details
Main Authors: Ming Yan, Cheng Peng, Xueyan Lang, Yilan Li, Yao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
sorafenib
cardiotoxicity
ATF3
NDUFS1
ER stress
mitochondrial dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1593290/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1593290/full

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