Activation of osteoblast ferroptosis by risperidone accelerates bone loss in mice models of schizophrenia

Abstract Background Ferroptosis is an iron-dependent regulatory cell death, which plays an essential role in bone loss. This study investigated whether the mechanism of risperidone (RIS)-induced bone loss is related to ferroptosis. Methods The schizophrenia mice were induced by administering MK-801....

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Bibliographic Details
Main Authors: Hongyan Fan, Zaihong Yang, Lan Pang, Peifan Li, Changrong Duan, Guangyuan Xia, Lei Zheng
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Orthopaedic Surgery and Research
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Online Access:https://doi.org/10.1186/s13018-025-05520-w
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