Mathematical multi-compartment modeling of chronic lymphocytic leukemia cell kinetics under ibrutinib

Summary: The Bruton tyrosine kinase inhibitor ibrutinib is an effective treatment for patients with chronic lymphocytic leukemia (CLL). While it rapidly reduces lymph node and spleen size, it initially increases the number of lymphocytes in the blood due to cell redistribution. A previously publishe...

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Bibliographic Details
Main Authors: Melanie Schulz, Sanne Bleser, Manouk Groels, Dragan Bošnački, Jan A. Burger, Nicholas Chiorazzi, Carsten Marr
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224024672
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