Associations between weight gain, integrase inhibitors antiretroviral agents, and gut microbiome in people living with HIV: a cross-sectional study

Associations between weight gain, integrase inhibitors antiretroviral agents, and gut microbiome in people living with HIV: a cross-sectional study

Abstract Dolutegravir and bictegravir are second-generation HIV integrase strand transfer inhibitors (INSTIs) that were previously associated with abnormal weight gain. This monocentric cross-sectional study investigates associations between weight gain during the first year after initiation of dolu...

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Bibliographic Details
Main Authors: Julien De Greef, Khoi Nguyen Nguyen, Matthias Van Hul, Anthony Puel, Jean Cyr Yombi, Bernard Vandercam, Anne Vincent, Laure Elens, Leïla Belkhir, Vincent Haufroid, Patrice D. Cani
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Microbiota
Dolutegravir
Bictegravir
Tenofovir alafenamide
Weight gain
Dysosmobacter welbionis
Online Access:https://doi.org/10.1038/s41598-025-06500-0
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https://doi.org/10.1038/s41598-025-06500-0

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