A dendritic cell vaccine for both vaccination and neoantigen-reactive T cell preparation for cancer immunotherapy in mice

A dendritic cell vaccine for both vaccination and neoantigen-reactive T cell preparation for cancer immunotherapy in mice

Abstract Adoptive cell transfer (ACT) using neoantigen-specific T cells is an effective immunotherapeutic strategy. However, the difficult isolation of neoantigen-specific T cells limits the clinical application of ACT. Here, we propose a method to prepare neoantigen-reactive T cells (NRT) for ACT f...

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Main Authors: Qing Li, Hao Zeng, Ting Liu, Peipei Wang, Rui Zhang, Binyan Zhao, Tang Feng, Yuling Yang, Jiumei Wu, Yue Zheng, Bailing Zhou, Yang Shu, Heng Xu, Li Yang, Zhenyu Ding
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54650-y
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https://doi.org/10.1038/s41467-024-54650-y

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