Microglial cyclooxygenase-1 modulates cerebral capillary basal tone in vivo in mice

Microglial cyclooxygenase-1 modulates cerebral capillary basal tone in vivo in mice

Abstract Microglia and border associated macrophages have been implicated in hypercapnia, but it is unknown which myeloid cell modulates which vessel type. Previously, we documented in mice myeloid cell association with the brain vasculature but did not distinguish their localization along the vascu...

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Main Authors: William A. Mills, Niesha A. Savory, Aida Oryza Lopez-Ortiz, Dennis H. Lentferink, Fernando González Ibáñez, Praise Agochi, Elina Rastegar, Arnav Gupta, Deetya Gupta, Arya Suram, Brant E. Isakson, Marie-Ève Tremblay, Ukpong B. Eyo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60753-x
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https://doi.org/10.1038/s41467-025-60753-x

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