Coupled pre‐mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli

Coupled pre‐mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli

Abstract Transcriptional responses to extracellular stimuli involve tuning the rates of transcript production and degradation. Here, we show that the time‐dependent profiles of these rates can be inferred from simultaneous measurements of precursor mRNA (pre‐mRNA) and mature mRNA profiles. Transcrip...

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Bibliographic Details
Main Authors: Amit Zeisel, Wolfgang J Köstler, Natali Molotski, Jonathan M Tsai, Rita Krauthgamer, Jasmine Jacob‐Hirsch, Gideon Rechavi, Yoav Soen, Steffen Jung, Yosef Yarden, Eytan Domany
Format: Article
Language:English
Published: Springer Nature 2011-09-01
Series:Molecular Systems Biology
Subjects:
half‐life
operational strategy
pre‐mRNA
transcriptional response
Online Access:https://doi.org/10.1038/msb.2011.62
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https://doi.org/10.1038/msb.2011.62

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