The DNA mismatch repair protein, MSH6 is a novel regulator of PD-L1 expression

The DNA mismatch repair protein, MSH6 is a novel regulator of PD-L1 expression

Immune checkpoint inhibitors (ICIs) are extremely effective in a subgroup of mismatch repair-deficient (MMRd) cancers, but ∼50% remain resistant to treatment. We have shown for the first time that this may be due to the differential regulation of factors linked to response to ICIs upon loss of the d...

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Bibliographic Details
Main Authors: Kirsten Brooksbank, Charlotte Smith, Eleni Maniati, Amy Gibson, Wai Yiu Tse, Amy Kate Hall, Jun Wang, Tyson V Sharp, Sarah A Martin
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Mismatch repair
MSH6
Transcription factor
PD-L1
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000879
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