Combining the RCAS/tv-a retrovirus and CRISPR/Cas9 gene editing systems to generate primary mouse models of diffuse midline glioma

Combining the RCAS/tv-a retrovirus and CRISPR/Cas9 gene editing systems to generate primary mouse models of diffuse midline glioma

Diffuse midline gliomas (DMGs) are lethal brain tumors that arise in children and young adults, resulting in a median survival of less than two years. Genetically engineered mouse models (GEMMs) are critical to studying tumorigenesis and tumor-immune interactions, which may inform new treatment appr...

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Bibliographic Details
Main Authors: Sophie R. Wu, Julianne Sharpe, Joshua Tolliver, Abigail J. Groth, Reid Chen, María E. Guerra García, Vennesa Valentine, Nerissa T. Williams, Sheeba Jacob, Zachary J. Reitman
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Diffuse midline glioma
Midline glioma
CRISPR
Retrovirus
Genetic mouse model
Cre/loxP
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000181
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http://www.sciencedirect.com/science/article/pii/S1476558625000181

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