Aprepitant-loaded solid lipid nanoparticles: a novel approach to enhance oral bioavailability

Aprepitant-loaded solid lipid nanoparticles: a novel approach to enhance oral bioavailability

Objectives of the present study are the development of aprepitant (APT)-loaded solid lipid nanoparticles (SLNs) using the polymers poloxamer 407 and β-cyclodextrin for enhanced solubility and their pharmacokinetic analysis. APT-loaded SLNs were prepared by the precipitation method and characterized...

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Bibliographic Details
Main Authors: Mazhar Hussain, Muhammad Farooq, Muhammad Asad Saeed, Muhammad Ijaz, Sherjeel Adnan, Zeeshan Masood, Muhammad Waqas, Wafa Ishaq, Nabeela Ameer
Format: Article
Language:English
Published: Beilstein-Institut 2025-05-01
Series:Beilstein Journal of Nanotechnology
Subjects:
aprepitant
β-cyclodextrin
pharmacokinetic study
poloxamer
solid lipid nanoparticles
Online Access:https://doi.org/10.3762/bjnano.16.50
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https://doi.org/10.3762/bjnano.16.50

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