N-acetylaspartate mitigates pro-inflammatory responses in microglial cells by intersecting lipid metabolism and acetylation processes

N-acetylaspartate mitigates pro-inflammatory responses in microglial cells by intersecting lipid metabolism and acetylation processes

Abstract Background Microglia play a crucial role in brain development and repair by facilitating processes such as synaptic pruning and debris clearance. They can be activated in response to various stimuli, leading to either pro-inflammatory or anti-inflammatory responses associated with specific...

Full description

Saved in:
Bibliographic Details
Main Authors: Federica Felice, Pamela De Falco, Martina Milani, Serena Castelli, Antonella Ragnini-Wilson, Giacomo Lazzarino, Nadia D’Ambrosi, Fabio Ciccarone, Maria Rosa Ciriolo
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell Communication and Signaling
Subjects:
Microglial polarization
NAA
Anti-inflammatory response
Oxidative metabolism
Lipid turnover
Histone deacetylases
Online Access:https://doi.org/10.1186/s12964-024-01947-6
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12964-024-01947-6

Similar Items