Exploring extracellular vesicles as novel therapeutic agents for intervertebral disc degeneration: delivery, applications, and mechanisms

Exploring extracellular vesicles as novel therapeutic agents for intervertebral disc degeneration: delivery, applications, and mechanisms

Abstract Intervertebral disc degeneration is a multifactorial degenerative disease that poses a significant threat to the health of the elderly population. Current treatments primarily focus on physical therapy, medication, and surgery to alleviate symptoms associated with disc compression but do no...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yuxin Jin, Ouqiang Wu, Zhihua Chen, Linjie Chen, Kai Zhang, Qizhu Chen, Haijun Tian, Xinzhou Wang, Morgan Jones, Kenny Yat Hong Kwan, Yan Michael Li, Pooyan Makvandi, Xiangyang Wang, Xiang Hai, Jun Zhang, Aimin Wu
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Series:	Stem Cell Research & Therapy
Subjects:	Intervertebral disc degeneration Lower back pain Extracellular vesicles Exosomes
Online Access:	https://doi.org/10.1186/s13287-025-04299-1
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The dual effects of iron deficiency on intervertebral disc development and on acute injury-induced disc degeneration
by: Hengrui Chang, et al.
Published: (2025-06-01)

Tissue engineering strategies for treating intervertebral disc degeneration
by: Guangshuai Nie, et al.
Published: (2025-07-01)

Assessment of the Concentration of Transforming Growth Factor Beta 1–3 in Degenerated Intervertebral Discs of the Lumbosacral Region of the Spine
by: Rafał Staszkiewicz, et al.
Published: (2024-11-01)

Progress of smart material in the repair of intervertebral disc degeneration
by: Yisi Liu, et al.
Published: (2024-12-01)

Biomaterial-based circular RNA therapeutic strategy for repairing intervertebral disc degeneration
by: Hongze Chang, et al.
Published: (2025-03-01)

Natural products for intervertebral disc degeneration: mechanistic insights and therapeutic potentials
by: Zenghan Wu, et al.
Published: (2025-07-01)

Mechanisms and Therapeutic Strategies of Macrophage Polarization in Intervertebral Disc Degeneration
by: Kaiyuan Zheng, et al.
Published: (2025-06-01)

Research status and prospects of exosomes in the treatment of intervertebral disc degeneration
by: Feihong HUANG, et al.
Published: (2025-06-01)

Relation between grades of intervertebral disc degeneration and occupational activities of patients with lumbar disc herniation
by: Papić Monika, et al.
Published: (2017-01-01)

Therapeutic mechanisms of icariin in intervertebral disc degeneration: A critical narrative review
by: LiLun Zhong, et al.
Published: (2025-06-01)

A Bibliometric Study of Interleukin Cytokines in the Treatment of Intervertebral Disc Degeneration
by: Wang H, et al.
Published: (2025-07-01)

The pathogenesis and targeted therapies of intervertebral disc degeneration induced by cartilage endplate inflammation
by: Hantao Yang, et al.
Published: (2024-12-01)

Mitochondrial quality control: the real dawn of intervertebral disc degeneration?
by: Ba Qiu, et al.
Published: (2024-12-01)

Crosstalk Between Ferroptosis and Cuproptosis in Intervertebral Disc Degeneration: Mechanisms, Therapeutic Targets, and Future Directions
by: Zhongpan Li, et al.
Published: (2025-06-01)

Targeting Piezo1 channel to alleviate intervertebral disc degeneration
by: Feiyun Li, et al.
Published: (2025-03-01)

Quercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation
by: Jitian Li, et al.
Published: (2025-07-01)

Identification and Experimental Verification of Potential Immune Cell-Associated Gene Biomarkers in Human Intervertebral Disc Degeneration
by: Shi WH, et al.
Published: (2025-02-01)

Graph cut-based segmentation for intervertebral disc in human MRI
by: Leena Silvoster, et al.
Published: (2025-12-01)

Dual-pathological cascade delivery of apoptotic vesicles for targeted therapy in intervertebral disc degeneration
by: Wei Chen, et al.
Published: (2025-10-01)

Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration
by: Heng Chen, et al.
Published: (2024-12-01)

Hounsfield unit correlates with intervertebral disc degeneration in premenopausal and menopausal women: a radiological study
by: Ze Gao, et al.
Published: (2025-04-01)

Immune microenvironment in intervertebral disc degeneration: pathophysiology and therapeutic potential
by: Qian Ren, et al.
Published: (2025-07-01)

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress
by: Zaishi Zhu, et al.
Published: (2025-02-01)

Role of hypoxia-related genes and immune infiltration in intervertebral disc degeneration: molecular mechanisms and diagnostic potential
by: Kai Zhou, et al.
Published: (2025-07-01)

Inactivation of Tnf‐α/Tnfr signaling attenuates progression of intervertebral disc degeneration in mice
by: Chu Tao, et al.
Published: (2024-12-01)

Single‐Cell Analysis Integrated With Machine Learning Elucidates the Mechanisms of Nucleus Pulposus Cells Apoptosis in Intervertebral Disc Degeneration and Therapeutic Interventions
by: Chao Song, et al.
Published: (2025-03-01)

CXCL14 drives age-related intervertebral disc degeneration via NF-κB pathway activation in a multiomic study
by: Tianle Zhou, et al.
Published: (2025-07-01)

Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration
by: Christabel Thembela Dube, et al.
Published: (2025-02-01)

LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis
by: Fudong Li, et al.
Published: (2025-04-01)

Chronotherapy and intervertebral disc degeneration: understanding the role of circadian rhythm in degenerative processes
by: Cong Zhang, et al.
Published: (2025-06-01)

Apoptotic Pathway in Intervertebral Disc Degeneration: From Molecular Pathways to Clinical Interventions
by: Chae-Gwan Kong, et al.
Published: (2025-06-01)

Progress of melatonin in the treatment of intervertebral disc degeneration
by: Jianlin Yin, et al.
Published: (2025-05-01)

Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells
by: Xiaoqiang Wang, et al.
Published: (2024-12-01)

High impact works on stem cell transplantation in intervertebral disc degeneration
by: Xiaofeng Chen, et al.
Published: (2024-12-01)

The Significance of MAPK Signaling Pathway in the Diagnosis and Subtype Classification of Intervertebral Disc Degeneration
by: Yong Liu, et al.
Published: (2025-03-01)

Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degeneration
by: Shu Jia, et al.
Published: (2024-11-01)

Ipriflavone ameliorates intervertebral disc degeneration by inhibiting osteoporosis of vertebral body and pyroptosis of the nucleus pulposus in instability of lumbar spine and diabetic mice
by: Qi Sun, et al.
Published: (2025-08-01)

Analysis of Key Differential Metabolites in Intervertebral Disc Degeneration Based on Untargeted Metabolomics
by: Daqian Zhou, et al.
Published: (2025-03-01)

From structure to therapy: the critical influence of cartilaginous endplates and microvascular network on intervertebral disc degeneration
by: Yu Sun, et al.
Published: (2024-10-01)

Animal Models of Internal Endplate Injury-Induced Intervertebral Disc Degeneration: A Systematic Review
by: Yukun Ma, et al.
Published: (2024-01-01)