Engineered biological neuronal networks as basic logic operators

Engineered biological neuronal networks as basic logic operators

We present an in vitro neuronal network with controlled topology capable of performing basic Boolean computations, such as NAND and OR. Neurons cultured within polydimethylsiloxane (PDMS) microstructures on high-density microelectrode arrays (HD-MEAs) enable precise interaction through extracellular...

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Bibliographic Details
Main Authors: Joël Küchler, Katarina Vulić, Haotian Yao, Christian Valmaggia, Stephan J. Ihle, Sean Weaver, János Vörös
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Computational Neuroscience
Subjects:
neuron-on-a-chip
biocomputation
neural networks
neural circuit
Boolean
microelectrode array (MEA)
Online Access:https://www.frontiersin.org/articles/10.3389/fncom.2025.1559936/full
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https://www.frontiersin.org/articles/10.3389/fncom.2025.1559936/full

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