HNF4α inhibits the malignancy of intrahepatic cholangiocarcinoma by suppressing the Wnt signaling pathway

HNF4α inhibits the malignancy of intrahepatic cholangiocarcinoma by suppressing the Wnt signaling pathway

Previous studies have demonstrated that intrahepatic cholangiocarcinoma (ICC) may derive from transdifferentiation of hepatocytes, so transforming ICC cells into hepatocytes could be a potential strategy for treating ICC. Hepatocyte nuclear factor 4α (HNF4α), a master transcription factor in the liv...

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Bibliographic Details
Main Authors: Bo-Nan Xu, Cheng-Hong Ding, Yi-Long Liu, Yuan-Yuan Luo, Juan Deng, Shu-Qing Liu, Meng-Chao Xiao, Nan Jiang, Xin Zhang, Wen-Ping Xu, Wei-Fen Xie
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Translational Oncology
Subjects:
Hepatocyte nuclear factor 4α (HNF4α)
Intrahepatic cholangiocarcinoma (ICC)
Wnt signaling pathway
Isocitrate dehydrogenase 1(IDH1)
Online Access:http://www.sciencedirect.com/science/article/pii/S193652332500021X
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