Plasma levels of soluble PD-1, TIM-3, LAG-3 and galectin-3 and the degree of liver fibrosis in CHC and the impact of successful antiviral treatment on their levels

Plasma levels of soluble PD-1, TIM-3, LAG-3 and galectin-3 and the degree of liver fibrosis in CHC and the impact of successful antiviral treatment on their levels

Abstract Chronic hepatitis C (CHC), caused by the hepatitis C virus, commonly leads to liver fibrosis. CHC is also related to T-cell exhaustion, phenotypically manifesting as overexpression of inhibitory receptors (iRs), e.g., programmed death receptor-1 (PD-1), T cell immunoglobulin and mucin domai...

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Bibliographic Details
Main Authors: Sylwia Osuch, Aleksandra Kumorek, Paweł Kozłowski, Hanna Berak, Anna Maria Kochanowicz, Kamila Cortés-Fendorf
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
SPD-1
STIM-3
SLAG-3
Gal-3
Chronic hepatitis C
Liver fibrosis
Online Access:https://doi.org/10.1038/s41598-025-99096-4
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https://doi.org/10.1038/s41598-025-99096-4

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