GP73-dependent regulation of exosome biogenesis promotes colorectal cancer liver metastasis

GP73-dependent regulation of exosome biogenesis promotes colorectal cancer liver metastasis

Abstract Colorectal cancer (CRC) liver metastasis is the main cause of cancer-related mortality. How liver influences intercellular communication to support CRC liver metastasis remains unknown. Herein, we link GP73, whose chronic upregulation in hepatocytes triggers non-obese metabolic-dysfunction...

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Main Authors: Linfei Huang, Meng Wei, Huilong Li, Mingxin Yu, Luming Wan, Ruzhou Zhao, Qi Gao, Lijuan Sun, Xufeng Hou, Yunhai Mo, Qing Huang, Lan Zhen, Xiaopan Yang, Jingfei Li, Nan Wang, Chundong Zhang, Haoran Jin, Li Zhou, Yixin Xu, Haotian Lin, Xuhui Zhang, Boan Li, Yue Han, Jing Yuan, Rui Zhang, Feixiang Wu, Hui Zhong, Congwen Wei
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Cancer
Subjects:
Golgi protein 73
Exosome
Colorectal cancer
Metastasis
Online Access:https://doi.org/10.1186/s12943-025-02350-6
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https://doi.org/10.1186/s12943-025-02350-6

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