Effects of steroid-resistant nephrotic syndrome serum on AA pathway in podocytes cultured in 3D in vitro glomerular model

Effects of steroid-resistant nephrotic syndrome serum on AA pathway in podocytes cultured in 3D in vitro glomerular model

Abstract Steroid-resistant nephrotic syndrome (SRNS) is the most severe form of nephrotic syndrome, with genetic or unidentified immunological origins and rapidly progressing to the need for kidney replacement therapy. Lipotoxicity can affect podocytes inducing kidney damage. In this study, we evalu...

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Main Authors: Gaia Bianchi, Linda Bellucci, William Morello, Stefano Turolo, Giulia Cricrì, Federico Caicci, Chiara Tamburello, Stefania Villa, Daniele Prati, Giovanni Montini, Federica Collino
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Steroid-resistant idiopathic nephrotic syndrome (SRNS)
Three-dimensional (3D) glomerular model
Arachidonic acid (AA)
Slit diaphragm proteins
Online Access:https://doi.org/10.1038/s41598-025-95216-2
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https://doi.org/10.1038/s41598-025-95216-2

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