Semi-rational design of an aromatic dioxygenase by substrate tunnel redirection

Summary: Lignin valorization is crucial for achieving economic and sustainable biorefinery processes. However, the enzyme substrate preferences involved in lignin degradation remain poorly understood, and low activity toward specific substrates presents a significant challenge to the efficient utili...

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Bibliographic Details
Main Authors: Jiawei Wang, Xingyu Ouyang, Shiyu Meng, Jiayi Li, Liangxu Liu, Chaofeng Li, Hengrun Li, Haotian Zheng, Chao Liao, Yi-Lei Zhao, Jun Ni
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224027974
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