Coherent Raman microscopy visualizes ongoing cellular senescence through amide I peak shifts originating from β sheets in disordered nucleolar proteins

Coherent Raman microscopy visualizes ongoing cellular senescence through amide I peak shifts originating from β sheets in disordered nucleolar proteins

Abstract Cellular senescence occurs through the accumulation of many kinds of stresses. Senescent cells in tissues also cause various age-related disorders. Therefore, detecting them without labeling is beneficial for medical research and developing diagnostic methods. However, existing biomarkers h...

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Bibliographic Details
Main Authors: Shigeo Ishibashi, Akihito Inoko, Yuki Oka, Philippe Leproux, Hideaki Kano
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Cellular senescence
Nucleolus
LLPS (liquid-liquid phase separation)
Raman
Amide I
Coherent anti-stokes Raman scattering (CARS) microscopy
Online Access:https://doi.org/10.1038/s41598-024-78899-x
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https://doi.org/10.1038/s41598-024-78899-x

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