Tanshinone IIA suppresses the proliferation and fibrosis of mesangial cell in diabetic nephropathy though WTAP-mediated m6A methylation

Tanshinone IIA suppresses the proliferation and fibrosis of mesangial cell in diabetic nephropathy though WTAP-mediated m6A methylation

Abstract Diabetic nephropathy (DN) is often accompanied by mesangial cell proliferation and fibrosis. Tanshinone IIA (Tan-IIA) is the main fat-soluble component of Salvia miltiorrhiza. N6-Methyladenosine (m6A) modification is a widely studied epigenetic mechanism. This study aimed to investigate the...

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Bibliographic Details
Main Authors: Hao Peng, Xiaoyan Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Diabetic nephropathy
Tanshinone IIA
m6A
Proliferation
Fibrosis
WTAP
Online Access:https://doi.org/10.1038/s41598-025-03738-6
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https://doi.org/10.1038/s41598-025-03738-6

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