Extensive Bone Marrow Involvement by BRAFV660E-Mutated Bi-Phenotypic Erdheim-Chester Neoplasm/Rosai-Dorfman Disease (Mixed Histiocytic Neoplasm) with Atypical Histological Features and Fulminant Hemophagocytosis

Extensive Bone Marrow Involvement by BRAFV660E-Mutated Bi-Phenotypic Erdheim-Chester Neoplasm/Rosai-Dorfman Disease (Mixed Histiocytic Neoplasm) with Atypical Histological Features and Fulminant Hemophagocytosis

Background: Erdheim-Chester disease (ECD) is a recently recognized clonal hematopoietic neoplasm characterized by activating alterations in the MAPK pathway. It involves multi-organ accumulation of abnormal histiocytes, leading to nonspecific clinical manifestations due to inflammation an...

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Main Authors: Dina Soliman, Firyal Ibrahim, Hasan Rizvi, Mahir Petkar, Zsolt Lengyel, Aliya Habib Sange, Awni Alshurafa, Ruba Yasin
Format: Article
Language:English
Published: Karger Publishers 2025-05-01
Series:Case Reports in Oncology
Online Access:https://karger.com/article/doi/10.1159/000545775
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https://karger.com/article/doi/10.1159/000545775

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