A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells.

A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells.

Myosin VI, found in organisms from Caenorhabditis elegans to humans, is essential for auditory and vestibular function in mammals, since genetic mutations lead to hearing impairment and vestibular dysfunction in both humans and mice. Here, we show that a missense mutation in this molecular motor in...

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Main Authors: Ronna Hertzano, Ella Shalit, Agnieszka K Rzadzinska, Amiel A Dror, Lin Song, Uri Ron, Joshua T Tan, Alina Starovolsky Shitrit, Helmut Fuchs, Tama Hasson, Nir Ben-Tal, H Lee Sweeney, Martin Hrabe de Angelis, Karen P Steel, Karen B Avraham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-10-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000207&type=printable
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