Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

The two identical motor domains (heads) of dimeric kinesin-1 move in a hand-over-hand process along a microtubule, coordinating their ATPase cycles such that each ATP hydrolysis is tightly coupled to a step and enabling the motor to take many steps without dissociating. The neck linker, a structural...

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Bibliographic Details
Main Authors: Yamato Niitani, Kohei Matsuzaki, Erik Jonsson, Ronald D Vale, Michio Tomishige
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
molecular motor
cytoskeleton
kinetics
Online Access:https://elifesciences.org/articles/106228
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https://elifesciences.org/articles/106228

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