Niacin‐mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination

Niacin‐mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination

Abstract Charcot–Marie–Tooth (CMT) neuropathies are highly heterogeneous disorders caused by mutations in more than 70 genes, with no available treatment. Thus, it is difficult to envisage a single suitable treatment for all pathogenetic mechanisms. Axonal Neuregulin 1 (Nrg1) type III drives Schwann...

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Main Authors: Alessandra Bolino, Françoise Piguet, Valeria Alberizzi, Marta Pellegatta, Cristina Rivellini, Marta Guerrero‐Valero, Roberta Noseda, Chiara Brombin, Alessandro Nonis, Patrizia D'Adamo, Carla Taveggia, Stefano Carlo Previtali
Format: Article
Language:English
Published: Springer Nature 2016-10-01
Series:EMBO Molecular Medicine
Subjects:
animal models
Charcot–Marie–Tooth neuropathies
myelin
Neuregulin 1
nicotinic acid
Online Access:https://doi.org/10.15252/emmm.201606349
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https://doi.org/10.15252/emmm.201606349

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