Aspergillus fumigatus secondary metabolite pyripyropene is important for the dual biofilm formation with Pseudomonas aeruginosa

Aspergillus fumigatus secondary metabolite pyripyropene is important for the dual biofilm formation with Pseudomonas aeruginosa

ABSTRACT The human pathogenic fungus Aspergillus fumigatus establishes dual biofilm interactions in the lungs with the pathogenic bacterium Pseudomonas aeruginosa. Screening of 21 A. fumigatus null mutants revealed seven mutants (two G protein-coupled receptors, three mitogen-activated protein kinas...

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Main Authors: Patricia Alves de Castro, Daniel Yuri Akiyama, Camila Figueiredo Pinzan, Thaila Fernanda dos Reis, Endrews Delbaje, Peter Rocha, Mario Augusto Izidoro, Sérgio Schenkman, Shinya Sugimoto, Norio Takeshita, Karin Steffen, Jessica L. Aycock, Stephen K. Dolan, Antonis Rokas, Taícia Fill, Gustavo H. Goldman
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
Aspergillus fumigatus
Pseudomonas aeruginosa
biofilm formation
G-protein signaling
secondary metabolites
pyripyropene
Online Access:https://journals.asm.org/doi/10.1128/mbio.00363-25
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https://journals.asm.org/doi/10.1128/mbio.00363-25

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