Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Abstract While checkpoint immunotherapy effectively mobilizes T‐cell responses against tumors, its success in hepatocellular carcinoma (HCC) is frequently undermined by immunosuppressive myeloid cells within the tumor microenvironment. This study investigates the role of nuclear protein 1 (NUPR1), a...

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Main Authors: Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
histone lactylation
immune checkpoint blockade
MAPK pathway
nuclear protein 1
tumor‐associated macrophages (TMA)
Online Access:https://doi.org/10.1002/advs.202413095
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https://doi.org/10.1002/advs.202413095

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