Intrapleural dual blockade of IL-6 and PD-L1 reprograms CAF dynamics and the tumor microenvironment in lung cancer-associated malignant pleural effusion

Intrapleural dual blockade of IL-6 and PD-L1 reprograms CAF dynamics and the tumor microenvironment in lung cancer-associated malignant pleural effusion

Abstract Background Malignant pleural effusion (MPE) is a severe complication in lung cancer, characterized by an immunosuppressive tumor microenvironment (TME) and limited therapeutic options. This study investigates the role of IL-6 in regulating immune suppression and tumor progression in MPE and...

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Main Authors: Qinpei Cheng, Xueying Zuo, Zimu Wang, Wanjun Lu, Yuxin Jiang, Jiaxin Liu, Xinying Li, Qiuli Xu, Suhua Zhu, Xin Liu, Yong Song, Ping Zhan, Tangfeng Lv
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Respiratory Research
Subjects:
Malignant pleural effusion
Lung cancer
IL-6
PD-L1
Cancer-associated fibroblast
Immunotherapy
Online Access:https://doi.org/10.1186/s12931-025-03263-0
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https://doi.org/10.1186/s12931-025-03263-0

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