Integrative bioinformatics analysis and experimental validation identify CHEK1 as an unfavorable prognostic biomarker related to immunosuppressive phenotypes in soft tissue sarcomas

Integrative bioinformatics analysis and experimental validation identify CHEK1 as an unfavorable prognostic biomarker related to immunosuppressive phenotypes in soft tissue sarcomas

Abstract Soft tissue sarcomas (STS), including rhabdomyosarcoma (RMS), exhibit significant heterogeneity and limited responsiveness to immune checkpoint blockade (ICB). Unsupervised tumor immune phenotype based on multi-omics expression profiling of STS has been less studied. To reveal the tumor imm...

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Main Authors: Chao Rong, Yun Liu, Fang Xiang, Xin Zhao, Jinjin Zhang, Zuorun Xiao, Jinsha Wang, Lin Chen, Zhiqi Guo, Ziyu Zhang, Jingnan An, Jing Shen, Jochen Hess, Xiaodong Yuan, Qiong Zhang, Shouli Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01064-8
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https://doi.org/10.1038/s41698-025-01064-8

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