D2HGDH Deficiency Regulates Seizures through GSH/Prdx6/ROS‐Mediated Excitatory Synaptic Activity

D2HGDH Deficiency Regulates Seizures through GSH/Prdx6/ROS‐Mediated Excitatory Synaptic Activity

Abstract Current antiepileptic drugs are ineffective in one‐third of patients with epilepsy; however, identification of genes involved in epilepsy can enable a precision medicine approach. Here, it is demonstrated that downregulating D‐2‐hydroxyglutarate dehydrogenase (D2HGDH) enhances susceptibilit...

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Bibliographic Details
Main Authors: Zhijuan Zhang, Hui Zhang, Peng Zhang, Rong Li, Jinyu Zhou, Jiyuan Li, Danmei Hu, Rui Huang, Fenglin Tang, Jie Liu, Demei Xu, Chenlu Zhang, Xin Tian, Yuanlin Ma, Patrick Kwan
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
D‐2‐hydroxyglutarate dehydrogenase
epilepsy
excitatory synapses
reactive oxygen species
Online Access:https://doi.org/10.1002/advs.202404488
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https://doi.org/10.1002/advs.202404488

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