Novel NUDCD1 gene variant predisposes to severe COVID-19 disease in Asians through modulation of antiviral DHX15- and MAVS-mediated signalling

Novel NUDCD1 gene variant predisposes to severe COVID-19 disease in Asians through modulation of antiviral DHX15- and MAVS-mediated signalling

BackgroundGenome-wide associative studies can potentially uncover novel pathways which modulate anti-viral immune responses against SARS-CoV-2 or identify drivers of severe disease. To date, these studies have yielded loci mostly in non-functional domains of unknown biological significance and invar...

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Main Authors: Aseervatham Anusha Amali, Douglas Jie Wen Tay, Yiqi Seow, Marie Loh, Sharada Ravikumar, Jocelyn Jin Yu, Shaun Seh Ern Loong, Siew Wai Fong, Chang Jie Mick Lee, Jonathan Jordon Cailu Lim, Louis Hanqiang Gan, Winston Lian Chye Koh, Ying Ding, Qi Hui Sam, Zhaohong Tan, Rachel Ying Min Tan, Chong Boon Lua, Justin Jang Hann Chu, Amit Singhal, Shyam Prabhakar, Wee Joo Chng, Laurent Renia, David Chien Boon Lye, Lisa F. P. Ng, Kai Sen Tan, Roger Foo, Chang Chuan Melvin Lee, Barnaby Young, Louis Yi Ann Chai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
innate immunity
DEAH-Box helicase
type I interferon
Southeast Asia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1581293/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1581293/full

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