Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics

Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics

Abstract Antibiotic‐resistant enterococci represent a significant global health challenge. Unfortunately, most β‐lactam antibiotics are not applicable for enterococcal infections due to intrinsic resistance. To extend their antimicrobial spectrum, polycationic peptides are conjugated to examples fro...

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Main Authors: Julia Werner, Florian Umstätter, Manuel B. Böhmann, Hannah Müller, Barbro Beijer, Tobias Hertlein, Laura Kaschnitz, Veronika Bram, Christian Kleist, Karel D. Klika, Eric Mühlberg, Gabriel Braune, Sabrina Wohlfart, Martin Gärtner, Silke Peter, Stefan Zimmermann, Uwe Haberkorn, Knut Ohlsen, Heike Brötz‐Oesterhelt, Walter Mier, Philipp Uhl
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
enterococci
polycationic peptides
resistance
β‐lactam antibiotics
Online Access:https://doi.org/10.1002/advs.202411406
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https://doi.org/10.1002/advs.202411406

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