Langerhans Cells Directly Interact with Resident T Cells in the Human Epidermis

Langerhans Cells Directly Interact with Resident T Cells in the Human Epidermis

Adult human skin contains nearly twice as many T cells as the peripheral blood, which include tissue-resident memory T cells. However, the precise mechanisms maintaining tissue-resident memory T cells in the healthy skin remain unclear. Using normal human skin samples, we find that Langerhans cells...

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Bibliographic Details
Main Authors: Tomonori Oka, Tatsuya Hasegawa, Truelian Lee, Valeria S. Oliver-Garcia, Mahsa Mortaja, Marjan Azin, Satoshi Horiba, Sabrina S. Smith, Sara Khattab, Kathryn E. Trerice, Steven T. Chen, Yevgeniy R. Semenov, Shadmehr Demehri
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:JID Innovations
Subjects:
Immune checkpoint
Langerhans cell
Peripheral tolerance
Regulatory T cell
Tissue-resident memory T cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2667026724000729
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http://www.sciencedirect.com/science/article/pii/S2667026724000729

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